Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221631 | Tetrahedron | 2010 | 5 Pages |
Abstract
The reaction of dihydrolipoic acid (DHLA) with 5-hydroxy-1,4-naphthoquinone (juglone) gives rise to the novel naphtho[1,4]dithiepine derivatives through ring expansion of an unstable spirocyclic 1,3-dithiane intermediate, which was isolated and completely characterized. Reported herein is also the characterization of novel reaction products of DHLA with other naphthoquinones and the extension of the study to the spirocyclic adduct formed by reaction with a representative 2-substituted naphthoquinone.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Giorgia Greco, Lucia Panzella, Alessandro Pezzella, Alessandra Napolitano, Marco d'Ischia,