Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221661 | Tetrahedron | 2011 | 6 Pages |
Abstract
An efficient and green one-pot synthesis route for tetrahydrochromene derivatives was developed. Lipase from Porcine pancreas (PPL) shows excellent catalytic activity and exerts good adaptability to different substrates in the reaction. All the reactions go smoothly and provide tetrahydrochromene derivatives with isolate yield up to 97% under room temperature. This lipase-catalyzed multistep conversion method has provided a new strategy to synthesize chromene derivatives and expanded the application of enzyme in organic synthesis.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiang-Cheng Xu, Wan-Mei Li, Hui Zheng, Yi-Feng Lai, Peng-Fei Zhang,