Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221730 | Tetrahedron | 2011 | 5 Pages |
Abstract
Multi-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, electrophile (bromine or iodine), and ketone or aldehyde under mild conditions proceeds smoothly to afford the functionalized H-pyrazolo[5,1-a]isoquinolines in good yields. This one-pot process involves intermolecular condensation, electrophilic cyclization, nucleophilic addition, intramolecular condensation, and aromatization. The resulting halo-containing H-pyrazolo[5,1-a]isoquinolines could be further elaborated via palladium-catalyzed cross-coupling reactions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xingxin Yu, Xiaolin Pan, Jie Wu,