Efficient synthesis of purines by inverse electron-demand Diels–Alder reactions of 1-substituted-1H-imidazol-5-amines with 1,3,5-triazines

The reaction of 1,3,5-triazine and 2,4,6-tri(trifluoromethyl)-1,3,5-triazine with in situ generated 1-substituted 5-amino-1H-imidazoles led to a set of functionalized purines. The developed practical route could serve as a fundament for the preparation of related ADA inhibitors.

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