| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221859 | Tetrahedron | 2010 | 7 Pages |
Abstract
l-Threonine has been found to be an efficient catalyst for the asymmetric α-hydroxymethylation of cyclohexanone with formalin. Reducing the amount of water in the reaction by the addition of magnesium sulfate as a dehydrating additive significantly improves the yield. Applications of (S)-2-hydroxymethyl cyclohexanone and the chiral building blocks derived therefrom for the synthesis of pharmaceutical compounds and natural products have been explored.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
