Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221870 | Tetrahedron | 2011 | 5 Pages |
Abstract
Carbocyclic nucleosides (â)-5â²-homocarbovir and (+)-epi-4â²-homocarbovir were prepared from an acylnitroso-derived hetero Diels-Alder cycloadduct. A kinetic enzymatic resolution generated an enantiopure aminocyclopentenol and Pd(0)-mediated decarboxylative allylations of allyl 2,2,2-trifluoroethyl malonates were used to install the 4â²-hydroxyethyl groups. Late stage derivatization gave access to the cyclopropylamine analogs, (â)-5â²-homoabacavir, and (+)-epi-4â²-homoabacavir. All carbonucleoside target molecules were evaluated for antiviral activity.
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Authors
Lawrence P. Jr., Marvin J. Miller, Jan Balzarini,