Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221916 | Tetrahedron | 2010 | 4 Pages |
Abstract
The asymmetric catalytic Michael reaction between isobutyraldehyde and nitroalkanes with chiral primary amine thiourea organocatalysts was described. In the presence of 10 mol % of 1-((1R,2R)-2-amino-1,2-diphenylethyl)-3-benzylthiourea, the desired products were achieved in excellent enantioselectivity (up to>99% ee) with up to 98% yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tianxiong He, Qing Gu, Xin-Yan Wu,