| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221943 | Tetrahedron | 2011 | 8 Pages |
Abstract
A practical and general synthesis of 1,3,6-trisubstituted quinolin-4(1H)-ones starting from 1-alkyl-6-bromo-3-iodoquinolin-4(1H)-one is described, based on regioselective sequential palladium-catalyzed cross-coupling reactions, namely Suzuki-Miyaura, Sonogashira and aminocarbonylation reactions, under microwave irradiation. Good substrate generality, ease of execution and practicability make this method exploitable for the generation of libraries of chemically diverse 4-quinolones.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claudia Mugnaini, Chiara Falciani, Maria De Rosa, Antonella Brizzi, Serena Pasquini, Federico Corelli,