| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222121 | Tetrahedron | 2010 | 7 Pages |
Abstract
A novel strategy to prepare 4-anilinoquinazoline derivatives based on the oxidation of the quinazoline ring is described. Quinazoline oxidation has been investigated and improved, thus leading to an efficient and high yielding method to quinazolin-4(3H)-ones. Efficiency of this approach has been evaluated synthesizing four well known tyrosine kinase inhibitors and comparing the obtained yields with those achievable through conventional synthetic methods.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Giovanni Marzaro, Adriano Guiotto, Giovanni Pastorini, Adriana Chilin,