Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222156 | Tetrahedron | 2009 | 10 Pages |
Abstract
Attempts toward the asymmetric synthesis of (â)-tetrahydrolipstatin are described. A palladium catalyzed Wacker-type reaction to convert an alkene to a ketone, highly diastereoselective reduction of a β-hydroxy ketone, selective oxidation of a diol, and modular synthesis are the key features of the successful approach.
Graphical abstractDownload full-size image A palladium catalyzed Wacker-type reaction, highly diastereoselective reduction of a β-hydroxy ketone, selective oxidation of a diol, and modular approach constitute the key features of the successful route to THL. Attempts at introducing the decyl chain employing an ene reaction failed.
Related Topics
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Authors
Sadagopan Raghavan, Kailash Rathore,