Article ID Journal Published Year Pages File Type
5222187 Tetrahedron 2011 7 Pages PDF
Abstract

Enantioselective synthesis of 16-membered trilactone macrolides, macrosphelide A and E from (S)-lactic acid is described. Key features of the synthesis include the utility of a hitherto unexplored β-ketophosphonate derived from lactic acid and Yamaguchi lactonization leading to the title compounds.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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