| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222200 | Tetrahedron | 2011 | 4 Pages |
Abstract
A facile and practical synthesis of 3,5-disubstituted isoxazoles via a silver-catalyzed cyclization and subsequent protonation of alkynyl oxime ethers has been developed. The methodology was successfully applied to the synthesis of a biologically active isoxazolecarboxylic acid.
Graphical abstractA facile and practical synthesis of 3,5-disubstituted isoxazoles via a silver-catalyzed cyclization and subsequent protonation of alkynyl oxime ethers has been developed. The methodology was successfully applied to the synthesis of a biologically active isoxazolecarboxylic acid.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masafumi Ueda, Yuki Ikeda, Aoi Sato, Yuta Ito, Maiko Kakiuchi, Hiroko Shono, Tetsuya Miyoshi, Takeaki Naito, Okiko Miyata,