Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222265 | Tetrahedron | 2011 | 10 Pages |
Abstract
The secondary amine nucleophilic addition to the nitroalkene was used to generate the active nitronate intermediate, followed by the sequential addition to aldehyde and ylide, giving the fully substituted isoxazoline-N-oxide in one-pot fashion. Mechanistic studies revealed the equilibrium nature of the diene intermediates, which provide the foundation for the asymmetric synthesis of this interesting heterocycles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheng Zhong, Lekh Nath S. Gautam, Dawei Wang, Novruz G. Akhmedov, Jeffrey L. Petersen, Xiaodong Shi,