Article ID Journal Published Year Pages File Type
5222265 Tetrahedron 2011 10 Pages PDF
Abstract

The secondary amine nucleophilic addition to the nitroalkene was used to generate the active nitronate intermediate, followed by the sequential addition to aldehyde and ylide, giving the fully substituted isoxazoline-N-oxide in one-pot fashion. Mechanistic studies revealed the equilibrium nature of the diene intermediates, which provide the foundation for the asymmetric synthesis of this interesting heterocycles.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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