| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222285 | Tetrahedron | 2009 | 6 Pages |
Abstract
The PhI(OAc)2-catalyzed aminobromination of electron-deficient olefins has been achieved in pure water with TsNH2 and NBS as nitrogen and bromine sources, respectively. With a catalytic amount of PhI(OAc)2, various olefins including α,β-unsaturated ketones, cinnamates, and cinnamides could be aminobrominated efficiently, giving the vicinal bromoamines in good yields and high regio- and diastereoselectivities. Utilizing water as solvent was crucial to realize this aminobromination reaction catalytically. The regioselectivity for the aminobromination of styrenes under the present aqueous conditions was also dramatically improved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xue-Liang Wu, Guan-Wu Wang,