Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222394 | Tetrahedron | 2011 | 8 Pages |
Abstract
Synthesis of the cyclic urea core structure of the HIV protease inhibitor DMP 450 has been achieved via W(CO)6/I2-catalyzed carbonylation of diamine intermediates. Carbonylations of related functionalized diamines to derivatives of the DMP 450 core structure were also examined. Selected diamine diol substrates could be converted to the cyclic urea core structure by catalytic carbonylation without protection of the diol functionality.
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Authors
Ampofo K. Darko, F. Chris Curran, Chloé Copin, Lisa McElwee-White,