Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222396 | Tetrahedron | 2011 | 6 Pages |
Abstract
A simple and efficient method for the enantioselective 1,6-Michael addition reaction of anthrone to a series of 3-methyl-4-nitro-5-alkenyl-isoxazoles with a bifunctional thiourea-tertiary amine as catalyst is described. This transformation proceeds smoothly with 10 mol % catalyst and provides a series of Michael adducts bearing 3-methyl-4-nitro-isoxazole and anthrone units with good to high enantioselectivities (up to 96% ee) and in very high yields (up to 99%).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong-Wei Sun, Yu-Hua Liao, Zhi-Jun Wu, Hao-Yu Wang, Xiao-Mei Zhang, Wei-Cheng Yuan,