Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
52224 | Catalysis Communications | 2008 | 6 Pages |
Abstract
The readily available amino alcohol 7 was employed into the [RuCl2(p-cymene)]2-catalyzed asymmetric transfer hydrogenation (ATH) of prochiral ketones performed in tap water. For the first time, the reaction was conducted in open-vessel at room temperature, providing moderate to good conversions and enantioselectivities. In addition, we have run some experiments to study the relationship between the structure of the chiral ligand and the catalytic efficiency. Surprisingly, N-substitution of 7 could lead to the inversion of the configuration of the product under the same conditions.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Zhou Xu, Jincheng Mao, Yawen Zhang, Jun Guo, Jinlong Zhu,