Article ID Journal Published Year Pages File Type
52224 Catalysis Communications 2008 6 Pages PDF
Abstract

The readily available amino alcohol 7 was employed into the [RuCl2(p-cymene)]2-catalyzed asymmetric transfer hydrogenation (ATH) of prochiral ketones performed in tap water. For the first time, the reaction was conducted in open-vessel at room temperature, providing moderate to good conversions and enantioselectivities. In addition, we have run some experiments to study the relationship between the structure of the chiral ligand and the catalytic efficiency. Surprisingly, N-substitution of 7 could lead to the inversion of the configuration of the product under the same conditions.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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