Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222405 | Tetrahedron | 2011 | 6 Pages |
Abstract
Ethyl 2-(trimethylsilyloxy)acrylic ester (1a) reacts with thioacetals providing the corresponding α-keto-γ-thio esters in good to satisfactory yields. Whereas aminals do not react, N,O-acetals lead to γ-amino-α-keto esters in good to excellent yields. All reactions proceed under mild reaction conditions, and no additional work up is required. Subsequent transformations of the obtained products to the corresponding α-oximes have been demonstrated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anke Krebs, Carsten Bolm,