| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222425 | Tetrahedron | 2009 | 13 Pages |
Abstract
Two stereoselective syntheses of SB-462795, a highly potent cathepsin K inhibitor, are described. Both routes feature a C5-C6 disconnection by ring closing metathesis to construct an azepane ring and are amenable to large-scale manufacturing.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Huan Wang, Hayao Matsuhashi, Brian D. Doan, Steven N. Goodman, Xi Ouyang, William M. Jr.,