One-pot three components synthesis of O-acetylcyanohydrins with TMSCN, acetic anhydride and carbonyl compounds under solvent-free condition

One-pot three components synthesis of O-acetylcyanohydrins has been developed in the presence of B(C6F5)3 as the catalyst. Variety of aldehydes or ketones reacts with TMSCN and acetic anhydride (Ac2O) under the influence of 1 mol % of B(C6F5)3 to give good to excellent yield of the products without solvent at rt.

Graphical abstractDownload full-size image Variety of aldehydes or ketones react with TMSCN and acetic anhydride (Ac2O) to give good to excellent yield of the O-acetylcyanohydrins under the influence of 1 mol % of B(C6F5)3 without solvent at rt. The major advantage of the method is the lowest catalyst quantity under solvent-free condition.