Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222435 | Tetrahedron | 2009 | 6 Pages |
Abstract
Cyclisations of N-alkyl and N,N-dialkyl cinnamic amides to the corresponding pyrrolidin-2-ones under the conditions of flash vacuum thermolysis (FVT), are described. It was found that these reactions proceed at 950-1000 °C affording in various yields the mixtures of isomeric mono and bicyclic γ-lactams, which were separated chromatographically and analysed by means of NMR spectroscopy. Two alternative mechanisms for the title process are proposed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
StanisÅaw LeÅniak, Ryszard B. Nazarski, Beata Pasternak,