| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222451 | Tetrahedron | 2010 | 6 Pages |
Abstract
Condensation of carboxylic acids with alcohols, phenols and thiols proceeded smoothly to afford carboxylic acid alkyl esters, phenolic esters and thioesters by using the combination of chlorodiphenylphosphine, imidazole and molecular iodine in refluxing acetonitrile. Esterification with this mixed reagent system gave the corresponding products in excellent yields. The phosphorus-containing byproduct was simply removed from the organic phase by basic aqueous workup without the need for chromatography purification.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
