Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222470 | Tetrahedron | 2009 | 7 Pages |
Abstract
An efficient Pd(0)-catalyzed Buchwald-Hartwig protocol for the facile preparation of N-aryl and N-heteroaryl substituted homopiperazines is described. The syntheses proceeded with aryl- and heteroaryl halides in high yields using X-Phos as best ligand. The C-N coupling products were prepared both under conventional as well as microwave heating conditions and examples for microwave-assisted upscaling are included in this study.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Uwe Schön, Josef Messinger, M. Buckendahl, M.S. Prabhu, A. Konda,