| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222474 | Tetrahedron | 2009 | 7 Pages |
Abstract
A new cyclic nitrone spin trap, [4-(3â²,3â²-dibutyl-2â²-oxy-3â²H-isoindol-5â²-yloxy)butyl]triphenylphosphonium bromide (MitoSpin), bearing a lipophilic cation has been prepared by a route that involves a novel Parham-type lithiation-cyclization of an isocyanate to give the isoindolinone core. MitoSpin accumulates in a membrane potential dependent way in energized mitochondria and its oxidation could potentially be used in the study of oxidative stress resulting from reactive oxygen species generated in mitochondria.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Caroline Quin, Jan Trnka, Alison Hay, Michael P. Murphy, Richard C. Hartley,