Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222489 | Tetrahedron | 2009 | 10 Pages |
Abstract
An approach towards the construction of bicyclic analogues of monoterpene alkaloids belonging to the kinabalurine, incarvilline and skytanthine families of natural products is reported. These syntheses rely on a stereoselective intramolecular Pauson–Khand cyclisation of a chiral pool-derived enyne in order to prepare the bicyclic core. Stereoselective further elaboration generates diastereomeric analogues of the naturally occurring alkaloids.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry