| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222491 | Tetrahedron | 2009 | 6 Pages |
Abstract
Rh2(OAc)4 catalyzed diazo decomposition of aryldiazoacetates in the presence of titanium(IV) isopropoxide generated oxonium ylide intermediates. Trapping of the oxonium ylide intermediates with imines occurred subsequently via a nucleophilic addition. The three-component reaction of aryldiazoacetates, titanium(IV) isopropoxide, and imines gave α-alkoxyl-β-amino acid derivatives with C-N/C-C bond formation in a single step. Extension of the study to a four-component reaction with in situ generated imine was also investigated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xu Zhang, Na Zhang, Xin Guo, Liping Yang, Wenhao Hu,