Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222552 | Tetrahedron | 2009 | 5 Pages |
Abstract
The synthesis of a propellane derivative of salinosporamide A having increased stability under physiological-like conditions is reported. The synthesis took advantage of a substrate-controlled stereoselective Ugi 4-center 3-component reaction to construct the required syn-bicyclic pyroglutamic acid framework.
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