Article ID Journal Published Year Pages File Type
5222552 Tetrahedron 2009 5 Pages PDF
Abstract

The synthesis of a propellane derivative of salinosporamide A having increased stability under physiological-like conditions is reported. The synthesis took advantage of a substrate-controlled stereoselective Ugi 4-center 3-component reaction to construct the required syn-bicyclic pyroglutamic acid framework.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry