| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222554 | Tetrahedron | 2009 | 8 Pages |
Abstract
A convergent formal synthesis of the antimitotic macrolide dictyostatin has been achieved. The C11-C26 fragment of dictyostatin was prepared via convergent assembly of the central deoxypropionate motif utilizing a site- and stereoselective titanium-mediated reductive cross-coupling and an asymmetric hydrogenation of the resulting stereodefined 1,3-diene.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Heidi L. Shimp, Glenn C. Micalizio,