| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222556 | Tetrahedron | 2009 | 6 Pages |
Abstract
The optimal conditions for the regioselective deprotection of per-N-Cbz-kanamycin A and the reaction mechanism was investigated. We found that the Cbz group at N-3â³ position was selectively deprotected under milder basic conditions and the cyclic carbamate is an intermediate of the deprotection reaction. The selective deprotection of the amine protecting group enable us to synthesize several kanamycin A dimers linked at N-3â³ position in a straightforward way.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gui-Hui Chen, Pan Pan, Ying Chen, Xiang-Bao Meng, Zhong-Jun Li,