Torrubiellutins A-C, from insect pathogenic fungus Torrubiella luteorostrata BCC 12904

Investigation of the insect pathogenic fungus Torrubiella luteorostrata led to the isolation of three new macrocyclic torrubiellutins A-C (1-3) and the known pyrone diterpene 4. Structures were elucidated by spectroscopic data including 1D, 2D NMR, and MS spectral data. The absolute stereochemistry was determined by chemical means using Mosher reactions and Marfey's reagent, together with NOESY spectral data. Torrubiellutin C showed biological activities against KB, MCF-7, NCI-H187, and Vero cell lines with IC50 varying from 0.78 to 4.36 μg/mL, while compound 4 exhibited antimalaria and anti-inflammatory activity with IC50 values of 3.49 and 1.21 μg/mL, respectively.

Graphical abstractDownload full-size imageMacrocyclic torrubiellutins A-C (1-3) isolated from the insect pathogenic fungus Torrubiella luteorostrata BCC 12904 and their biological activities were reported.