| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222597 | Tetrahedron | 2009 | 8 Pages |
Abstract
N′,N″-1H-Isoindole-1,3-diylidenedialkyl(aryl,heteroaryl)carbohydrazides were prepared in good yields via 1,1,3-trichloro-1H-isoindole, which was shown to be a versatile reagent for their synthesis. Tautomeric structure and conformational behaviour of dicarbohydrazides in solid state as well as in solution have been studied by X-ray crystallography, NMR spectroscopy and quantum calculations. The dependence of Z/E amide-type isomerism upon steric effects and solvent polarity is discussed.
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Physical Sciences and Engineering
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