| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222613 | Tetrahedron | 2010 | 6 Pages |
Syntheses of the bacterial surfactants 6S,6S-, 9S,9S-, and 9U,9U-flavolipids confirmed the structures proposed for them from spectroscopic analysis of a flavolipid mixture and made pure flavolipids available for the first time. All three synthetic flavolipids and a straight chain analogue were found to be weakly cytotoxic and to inhibit metastatic cancer cell migration, with 9U,9U-flavolipid (the most abundant natural flavolipid) having the most activity. Biosynthetic routes to the branched side-chains of the flavolipids are suggested, and it is proposed that branched chains are employed to hinder biodegradation.
Graphical abstractSeveral flavolipids were synthesized. In addition to their iron-scavenging activity, they were found to inhibit cancer cell migration.Figure optionsDownload full-size imageDownload as PowerPoint slide
