Article ID Journal Published Year Pages File Type
5222616 Tetrahedron 2010 6 Pages PDF
Abstract

A simple palladium(II)-catalyzed intramolecular addition of vinylpalladium species to ketones initiated by the carbopalladation of alkynamides under mild conditions without a Pd(II)/Pd(0) redox system was developed. This cascade reaction provides a new approach for the synthesis of highly substituted α-alkylidene-β-hydroxy-γ-lactams.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry