Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222665 | Tetrahedron | 2009 | 7 Pages |
Abstract
Optically active trans-N-Boc-cyclopentane- and cyclohexane-1,2-diamines (7) were prepared by a chemoenzymatic method from the corresponding (±)-trans-N,N-diallylcycloalkane-1,2-diamine. These mono-carbamates 7 (ee=99%) were used as the starting materials in the syntheses of different vicinal primary-tertiary diamines. Thus, by means of a simple three-step sequence involving a reductive-amination of an aromatic aldehyde with 7, N-methylation and finally, cleavage of the Boc group, several trans-N-(arylmethyl)-N-methylcyclopentane- and cyclohexane-1,2-diamines were obtained in high yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
F. Javier Quijada, Javier González-SabÃn, Francisca Rebolledo, Vicente Gotor,