| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222720 | Tetrahedron | 2011 | 4 Pages |
Abstract
A direct approach to 1,4-dihydropyridines by lipase-catalyzed unprecedented three-component Hantzsch-type reaction of aldehyde with 1,3-dicarbonyl compounds and acetamide in non-aqueous solvent has been developed. Some control experiments have been performed to demonstrate the specific catalytic effect of CAL-B. Acetamide was utilized as a novel ammonia source in the Hantzsch-type reaction for the first time. An array of 1,4-dihydropyridines was successfully synthesized through this methodology.
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