| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222730 | Tetrahedron | 2009 | 7 Pages |
Abstract
The direct asymmetric organocatalytic α-oxidation of aldehydes using trans-2-(p-methylphenylsulfonyl)-3-phenyloxaziridine is reported. This method affords the S isomer of α-hydroxy aldehydes, thereby complementing the selectivity for the R isomer observed using the two-step nitrosobenzene method. Use of α-methylproline and α-methylproline tetrazole significantly increases the enantioselectivity observed for the α-oxidation of aldehydes compared to analogous unsubstituted organocatalysts.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sok-Teng (Amy) Tong, Margaret A. Brimble, David Barker,