| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222764 | Tetrahedron | 2010 | 5 Pages |
Abstract
A simple, highly stereoselective three-step sequence for the enantioselective synthesis of cis-5-substituted proline esters is described. This sequence features an asymmetric PTC Michael addition, followed by acid catalysed imine exchange and catalytic hydrogenation. Application of this chemistry in the synthesis of the nonpeptide cholecystokinin antagonist (+)-RP-66803 11 is also described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Barry Lygo, Christopher Beynon, Michael C. McLeod, Claude-Eric Roy, Charles E. Wade,