| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222775 | Tetrahedron | 2010 | 11 Pages |
Abstract
3′-Alkyl-3-cyanomethyloxindoles, prepared by a palladium-catalyzed domino Heck/cyanation, were efficiently converted to spiropyrrolidinyl-, spiropiperidinyl- and spirocyclopropyl-oxindoles. The so-obtained spirooxindoles bearing three diversity points were further functionalized via selective N-acylation, N-alkylation, N-sulfonylation, SNAr reaction and Buchwald–Hartwig N-arylation reaction to reach diverse set of heterocycles.
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Physical Sciences and Engineering
Chemistry
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