| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222780 | Tetrahedron | 2010 | 4 Pages |
Abstract
A new combinatorial method for the preparation of substituted thiazolo[4,5-b]pyridines, which utilizes cyanoacetamide, heterocumulenes (isothiocyanates, carbon bisulfide), and ethyl-4-chloroacetoacetate in a new SN2→Thorpe–Ziegler→Thorpe–Guareschi domino reactions has been developed. The obtained thiazolo[4,5-b]pyridines were then used together with aldehydes and malononitrile in another Knoevenagel reaction→Michael reaction→hetero-Thorpe–Ziegler domino reaction for the synthesis of substituted 4,6-dihydro-5H-pyrano[2,3-d]thiazolo[4,5-b]pyridines.
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Related Topics
Physical Sciences and Engineering
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Organic Chemistry
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