| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222784 | Tetrahedron | 2010 | 8 Pages |
Abstract
The acyliminium cations derived from 4-vinyloxy- or 4-acyloxy-azetidin-2-ones in the presence of Lewis acids can alkylate nucleophilic arenes bound to the β-lactam nitrogen atom through methyloxy, or methylthio tethers. The reactions smoothly proceed to afford the corresponding 3-oxa- or 3-thia-4,5-benzocephams in a good yield. The sulfur atom can be easily removed by Raney nickel reduction to provide the title compounds.
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Physical Sciences and Engineering
Chemistry
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