Article ID Journal Published Year Pages File Type
5222811 Tetrahedron 2009 8 Pages PDF
Abstract

A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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