Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222825 | Tetrahedron | 2009 | 8 Pages |
Abstract
A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic δ-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite.
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