Article ID Journal Published Year Pages File Type
5222825 Tetrahedron 2009 8 Pages PDF
Abstract

A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic δ-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry