| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222886 | Tetrahedron | 2009 | 10 Pages |
Abstract
Tripeptide aldehydes, such as Z-Leu-Leu-Leu-H (MG-132), are an important class of compounds due to their biological activity. A new, general method for the synthesis of tripeptide aldehydes based on the multi-component Ugi reaction was developed. A careful choice of isocyanides makes it possible to obtain tripeptide precursors whose functionalization led to target structures. This method can be used for the preparation of tripeptide aldehydes with non-natural amino acid side chains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
MichaÅ Mroczkiewicz, Ryszard Ostaszewski,