| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5222889 | Tetrahedron | 2009 | 7 Pages |
Abstract
The synthesis of hitherto unknown C5-substituted O6,5â²-cyclouridines is described. The 2â²,3â²-isopropylidene-uridine was treated with N-halogenosuccinimides forming appropriate bridged 5-halogeno derivatives. Using lithiation method, bromine substituent at C5 position was exchanged into various alkyl and alkenyl derivatives.
Graphical abstractThe synthesis of hitherto unknown C5-substituted O6,5â²-cyclouridines is described. The 2â²,3â²-isopropylidene-uridine was treated with N-halogenosuccinimides forming appropriate bridged 5-halogeno derivatives. Using lithiation method, bromine substituent at C5 position was exchanged into various alkyl and alkenyl derivatives.Download full-size image
Related Topics
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Authors
Adam Mieczkowski, Pauline Peltier, Thomas Zevaco, Luigi A. Agrofoglio,