Article ID Journal Published Year Pages File Type
5222961 Tetrahedron 2010 9 Pages PDF
Abstract
Stereoselective ketoreductase-catalyzed reductions of α-substituted-β-hydroxy ketones are described. The stereoisomeric syn or anti 2-substituted-1,3-diols were prepared in high optical purities (>99% de, >99% ee) and high yields. This is a simple and highly stereoselective method for the synthesis of different diastereomers of chiral diols.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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