Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5222991 | Tetrahedron | 2009 | 6 Pages |
Abstract
Stereoselective total synthesis of α,β-unsaturated lactone (1a), isolated from Ravensara crassifolia, has been achieved efficiently starting from chiral 2,3-O-isopropylidene-d-glyceraldehyde (3) followed by asymmetric allylation and ring-closing metathesis. The antiproliferative activities of compounds 1a, 1b and the unusual bicyclic compound 2 were evaluated against three-cancer cell lines, THP-1 and U-937 (leukemia) and A-375 (melanoma).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Manchala Narasimhulu, Arepalli Sai Krishna, Janapala Venkateswara Rao, Yenamandra Venkateswarlu,