| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223184 | Tetrahedron | 2009 | 6 Pages |
Abstract
Sulfonamides of the non-natural amino acid homoproline and the dipeptide Pro-Phe were synthesised and evaluated for their catalytic activity in Michael and aldol reactions. Sulfonamides of homoproline outperform proline and Pro-Phe in the Michael reaction, whereas sulfonamides of Pro-Phe lead to better results in the aldol reaction. The results of the present study show that the conversion of the carboxylic group of either homoproline or dipeptide Pro-Phe to the bioisosteric acyl sulfonamide group lead to improved organocatalysts.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Evaggelia Tsandi, Christoforos G. Kokotos, Sofia Kousidou, Valentine Ragoussis, George Kokotos,