Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223186 | Tetrahedron | 2009 | 6 Pages |
Abstract
A regioselective access to both α- and γ-folic acid conjugates derived from archaeal lipid analogues is described. The synthetic approach is based on conveniently protected glutamates that led first to α- and γ-glutamate derivatives. The final reconstruction of the folic acid moiety was achieved through the reaction of a protected/activated pteroate followed by a simple deprotection step. These α- and γ-folic acid conjugates would permit to establish the importance of a regiocontrolled introduction of folic acid on the folic acid/folate receptor interaction in the case of a targeted drug/gene delivery.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Céline Lainé, Clémence Mocquet, Loïc Lemiègre, Thierry Benvegnu,