Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223239 | Tetrahedron | 2009 | 11 Pages |
Abstract
N-Acyliminium cyclization of 6-substituted (3Râ,6Râ,11aSâ)-3-arylmethyl-pyrazino[1,2-b]isoquinoline-1,4-diones gave with very good yields a novel tetrahydroisoquinoline pentacyclic core framework (29), while this reaction failed in all-cis-isomers to give instead conjugated enamines by deprotonation. Electronic and steric factors that govern the approach to both diastereomers from 6-substituted pyrazino[1,2-b]isoquinoline-1,4-diones have been studied.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Irene OrtÃn, Juan Francisco González, Elena de la Cuesta, Carmen Avendaño,