Article ID Journal Published Year Pages File Type
5223239 Tetrahedron 2009 11 Pages PDF
Abstract

N-Acyliminium cyclization of 6-substituted (3R∗,6R∗,11aS∗)-3-arylmethyl-pyrazino[1,2-b]isoquinoline-1,4-diones gave with very good yields a novel tetrahydroisoquinoline pentacyclic core framework (29), while this reaction failed in all-cis-isomers to give instead conjugated enamines by deprotonation. Electronic and steric factors that govern the approach to both diastereomers from 6-substituted pyrazino[1,2-b]isoquinoline-1,4-diones have been studied.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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