| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223242 | Tetrahedron | 2009 | 6 Pages |
Abstract
A short and enantioselective approach to medium ring ethers and its application to the syntheses of (â)-cis-lauthisan and (+)-isolaurepan are described. The synthetic strategy features Jacobson's Hydrolytic Kinetic Resolution (HKR), oxidative resolution of secondary alcohol, and highly diastereoselective Et3SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone to give exclusively the different medium-sized cis-disubstituted cyclic ethers.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Divya Tripathi, Satyendra Kumar Pandey, Pradeep Kumar,